Facilitated maturation of Ca handling properties of human embryonic stem cell-derived cardiomyocytes by calsequestrin expression
نویسندگان
چکیده
Jing Liu, Deborah K. Lieu, Chung Wah Siu, Ji-Dong Fu, Hung-Fat Tse, and Ronald A. Li Stem Cell Program and Department of Cell Biology and Human Anatomy, University of California Davis, Davis, California; Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children of North America, Sacramento, California; Stem Cell and Regenerative Medicine Program, Heart, Brain, Hormone and Healthy Aging Research Center, and Cardiology Division, Department of Medicine, The University of Hong Kong, Hong Kong
منابع مشابه
Facilitated maturation of Ca2+ handling properties of human embryonic stem cell-derived cardiomyocytes by calsequestrin expression.
Cardiomyocytes (CMs) are nonregenerative. Self-renewable pluripotent human embryonic stem cells (hESCs) can differentiate into CMs for cell-based therapies. We recently reported that Ca(2+) handling, crucial to excitation-contraction coupling of hESC-derived CMs (hESC-CMs), is functional but immature. Such immature properties as smaller cytosolic Ca(2+) transient amplitudes, slower kinetics, an...
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